Cutaneous Larva Migrans: Clinical Challenges and Insights from a Case Report with a Literature Review
Volume 10, Issue 2, Spring 2025, Pages 691-694
https://doi.org/10.30491/hpr.2025.508338.1476
Taher Elmi, Azam Ghorbannia Delavar, Majid Taheri, Hossein Torkashvand, Mojtaba Didehdar
Abstract Background: Cutaneous larva migrans (CLM) is a parasitic infection caused by the accidental penetration of canine hookworm larvae into the superficial layers of human skin. Although typically self-limiting, delayed diagnosis may result in complications such as secondary infections or allergic reactions.
Case Presentation: The case involved a 54-year-old man with a history of hypertension who presented with a creeping, erythematous lesion on his left leg, accompanied by severe pruritus and a history of contact with a pet dog. After confirming the dog’s hookworm infection and conducting further clinical evaluation, a diagnosis of CLM was established. Treatment with albendazole and an antihistamine resulted in complete resolution of the patient’s symptoms.
Conclusion: Although CLM is typically a self-limiting condition, timely initiation of treatment can significantly reduce the duration and severity of symptoms. The growing trend of pet ownership has increased the risk of CLM transmission, underscoring the importance of implementing effective preventive measures.
Molecular Identification and Evaluation of Drug Susceptibility of Candida Isolates from Bronchoalveolar Lavage Fluid in Patients with Hematological Malignancies
Volume 9, Issue 1, Winter 2024, Pages 396-401
https://doi.org/10.30491/hpr.2024.460378.1429
Faride Khanabadi, Taher Elmi, Zeinab Ghasemi, Mojtaba Didehdar, Mehraban Falahati, Rasol Aliannejad, Shirin Farahyar
Abstract Background: Different studies have shown that despite the expanding number of antifungal drugs, the death rate caused by Candida species has increased during the recent decades due to drug resistance occurrence.
Objectives: The present study aims to identify molecular structure and evaluate drug susceptibility in Candida species isolated from bronchoalveolar lavage fluid in patients diagnosed with hematological malignancies.
Methods: In this cross-sectional study, 54 clinical specimens were taken from the bronchoalveolar lavage of patients. The suspected colonies were investigated by microscopic examination and subsequent passages were evaluated according to standard operating procedures and specification of the type of colony color prescribed by CHROMagar to isolate the yeast. The sequencing method (ITS1, ITS4) was used to approve Candida species. Finally, susceptibility test was carried out according to M27S-3 and M38-A2 micro-dilution methods.
Results: Among 54 samples investigated with culture and PCR methods, 33 Candida species were identified in patients with hematological malignancies. Candida albicans (75.7%) was the most common fungal isolate. Results of drug susceptibility tests showed that the isolated C. albicans (n = 2), C. glabrata (n = 1), and C. tropicalis (n = 1) from patients with hematological malignancies were resistant to fluconazole. The present study showed that the prevalence of C. albicans was higher than other fungal species among patients with hematological malignancies.
Conclusion: Candida species are more susceptible to voriconazole, amphotericin B and Caspofungin. Therefore, identification of candida species along with their antifungal susceptibility pattern can help clinicians to better treat patients.