TY - JOUR ID - 113858 TI - Assessment of Inflammatory Markers in the Epidural Infusion of Bupivacaine-Fentanyl Compared to Morphine Bolus Injection in Gastrointestinal Cancer Surgeries JO - Hospital Practices and Research JA - HPR LA - en SN - 2476-390X AU - Madani, Seyed Jalal AU - Saeedi, Majid AU - Gheasi, Mohammad Saeed AU - Saghafinia, Masoud AU - Amouzegar, Seyed Mohammad Reza AU - Bahramifar, Ali AU - Shahkarami, Vahid AD - Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Y1 - 2020 PY - 2020 VL - 5 IS - 3 SP - 112 EP - 116 KW - Inflammatory Biomarker KW - Pain KW - Epidural Analgesic KW - Morphine DO - 10.34172/hpr.2020.21 N2 - Background: Gastrointestinal surgery is one of the procedures that result to produce inflammatory reactions and pain to patients. Administrate of high-safe analgesia in surgery is very essential, to reduce pain and improve inflammatory reactions. Objectives: The present study compared inflammatory markers and pain relief with the epidural infusion of bupivacaine-fentanyl and intravenous morphine bolus in gastrointestinal cancer surgeries. Methods: This randomized control clinical trial study was carried out from December 2018 to October 2020, on ASA I and II patients aged between 30-80 years who referred for gastrointestinal cancer surgery. Cases were randomly distributed into two groups. Group I received epidural catheter with bupivacaine (18 cases), and group II received fentanyl and morphine bolus injection (18 cases). On the first and second days post-operation, data on pain scores based on visual analogue scale (VAS) score, inflammatory markers (procalcitonin [PCT] and C-reactive protein [CRP]), platelet (PLT), white blood cells (WBCs), and erythrocyte sedimentation rate (ESR) was recorded. Results: The mean age was 52.21±16.13 years (41.6% male, 58.4 female). The mean of ESR, CRP and PCT postoperative were significantly higher than preoperative (P < 0.05). There were no differences between the two groups regarding PLT, ESR, CRP, and PCT preoperative postoperative (P > 0.05). The mean of pain was less in the epidural group than in the morphine group postoperative (P = 0.02). Conclusion: The results showed that epidural fentanyl-bupivacaine infusion was more effective in pain reduction than the intravenous infusion of morphine in cases undergoing gastrointestinal cancer operation. However, both analgesic approaches were similar in inflammatory functions. UR - https://www.jhpr.ir/article_113858.html L1 - https://www.jhpr.ir/article_113858_93fe92f6e6dfee884e2c5ab372f82ef2.pdf ER -