Document Type : Original Article


1 Physiology, Basic Medical Sciences. Olabisi Onabanjo University

2 Department of Surgery, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University

3 Department of Physiology, Faculty of Basic medical Sciences, Olabisi Onabanjo University.


Background: It is widely accepted that T2DM is preceded by a long pre-diabetic stage. Family studies have confirmed that the incidence of T2DM in first degree offspring of T2DM patients is higher when compared with control subjects. The baseline levels of HbA1c in offspring of T2 diabetes are important markers to development of Diabetes.
Objectives: This study was designed to assess the baseline HbA1c levels of normoglycemic offspring of Type 2 diabetes mellitus (T2DM) patients.
Methods: This study involved 100 offspring of T2DM patients (ODP) and 100 offspring of non-diabetic parents (ONDP) selected using random sampling method, aged between 16 and 40 years. Diabetic parents were exempted from the study. FBS was measured using Accucheck glucometer to exclude diabetes. Height, weight, serum HbA1c were measured using standard methods. BMI was calculated. Data was analyzed using descriptive statistic.
Results: The age range between 21and 25 years constituted the highest group 88(44.0%). 16(8.0%) of the study group were obese. 13(13.0%) were overweight. 150(75%) were normal-weight subjects. The mean HbA1c of 5.13%±0.03 in ODP subjects was significantly greater than that of ONDP subjects 4.76%±0.05 (p<0.05).
Conclusion: The serum HbA1c levels are higher among ODP than ONDP. The awareness of variations in these levels are precautionary measures since T2DM is long time predated to its development.