An Overview of the Relationship between Early-Onset Myocardial Infarction and Family History
Volume 10, Issue 3, Summer 2025, Pages 733-737
https://doi.org/10.30491/hpr.2025.536963.1501
Aydın Dursun, Mehmet Cem Başel, Hakan Güven, Nurullah Ay, Mustafa Boğan
Abstract Background: Sudden Cardiac Death (SCD) and Acute Coronary Syndrome (ACS) are major public health concerns, particularly in individuals with a family history of early-onset Coronary Artery Disease (CAD).
Objectives: The impact of family history on ACS and SCD risk remains underexplored.
Methods: This retrospective study included 689 patients diagnosed with ST-Elevation Myocardial Infarction (STEMI) who underwent Primary Percutaneous Coronary Intervention (PPCI) between January 2011 and June 2015. Patients with a parental history of SCD due to Myocardial Infarction (MI) were identified (n = 29, 4.2%). Demographic data, cardiovascular risk factors, and angiographic findings were evaluated.
Results: The median age at STEMI onset in patients with a parental history of SCD was 49 (41.5-52) years, 8.9 years younger than their parents’ age at SCD. Most patients were male (96%) and smokers (83%). Hyperlipidemia was present in 80%, although only 7% had been previously diagnosed. Multi-vessel disease was observed in 80%, and 28% required Coronary Artery Bypass Grafting (CABG). Two patients (7%) died due to cardiogenic shock.
Conclusion: Patients with a parental history of SCD develop STEMI at younger ages. Smoking and low HDL levels were key risk factors. Early screening and preventive measures, including smoking cessation and lipid control, were essential for high-risk individuals. Further studies are needed to explore genetic predisposition and targeted prevention strategies.
Impact of Age on Risk Factors and Clinical Manifestations of Acute Coronary Syndrome: Observations From the Coronary Care Unit of Sulaimani, Iraq
Volume 5, Issue 1, Winter 2020, Pages 28-34
https://doi.org/10.34172/hpr.2020.06
Amanj Abubakr Jalal Khaznadar, Rebin Wahid Salh
Abstract Background: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI ) are common types of acute coronary syndrome which are associated with the risk factors of age, obesity, hypertension, and diabetes.
Objective: The present study aimed to examine the effects of age on the risk factors and clinical symptoms of acute coronary syndrome.
Methods: A cross-section prospective study was conducted on 125 patients with acute coronary syndrome chosen by non-probability convenience sampling method in the coronary care unit in Sulaimani, the Kurdistan region of Iraq. Acute coronary syndrome types were diagnosed through clinical presentations, electrocardiography (ECG), and troponin test. Data was collected using a researcher-based checklist through face-to-face interviews.
Results: The results indicated that males were the dominant group. The age group 45-65 had the highest prevalence rate of acute coronary syndrome. The most frequent risk factors for acute coronary syndrome were hypertension (54.4%), dyslipidemia (52%), smoking (42.4%), and diabetes mellitus (38.4%). Typical chest pain was found to be the most frequent clinical presentation (88%). There was a significant difference between the age groups in terms of the effect of age on typical and atypical symptoms; however, neither age nor typical/atypical symptoms had a significant effect on type of acute coronary syndrome. Similarly, family history, hypertension, diabetes mellitus, obesity, smoking, physical inactivity, and dyslipidemia had no effect on type of acute coronary syndrome.
Conclusion: Age is a predictive factor for acute coronary syndrome, but family history, hypertension, diabetes mellitus, obesity, smoking, physical inactivity, and dyslipidemia cannot predict acute coronary syndrome.