%0 Journal Article %T Comparing the Efficacy of Amitriptyline and Melatonin on Tinnitus Treatment %J Hospital Practices and Research %I Baqiyatallah University of Medical Sciences %Z 2476-390X %A Chitsaz, Ahmad %A Rajol Dezfouli, Bahareh %A Rezaeian, Ahmad %D 2022 %\ 09/01/2022 %V 7 %N 3 %P 115-118 %! Comparing the Efficacy of Amitriptyline and Melatonin on Tinnitus Treatment %K Tinnitus %K Melatonin %K amitriptyline %R 10.34172/hpr.2022.23 %X Background: Tinnitus is described as the perception of sounds occurring in one or both ears or inside the human head without external auditory stimuli.Objectives: This study aimed to compare the efficacy of amitriptyline and melatonin in the treatment of tinnitus.Methods: This study was a randomized double-blind clinical trial of 60 patients referred to the neurology clinics of Kashani and Al-Zahra hospitals in Isfahan, Iran in 2020. Each patient was randomly assigned 1 code. Patients first filled in the THI and VAS questionnaires and were given either one of the two drugs (melatonin and amitriptyline) for 6 weeks. After collecting the desired information using an independent t test and paired t test in SPSS 26 software and error level of 0.05 the results were analyzed.Results: Thirty patients were in the amitriptyline group and 30 patients were in the melatonin group, of which 25 were men (41.7%) and 35 were women (58.3%) with a minimum age of 18 years and a maximum of 65 years. There was no significant difference between the reduction of tinnitus before and after taking the drugs based on VAS scale in amitriptyline and melatonin groups (P=0.234), however there was a significant difference between the effect of two amitriptyline and melatonin drugs on the reduction of tinnitus based on the THI questionnaire (P=0.018).Conclusion: The rate of tinnitus in patients decreased for 6 weeks with the use of amitriptyline and melatonin, but amitriptyline had a better effect on reducing the complications and pain of tinnitus. %U https://www.jhpr.ir/article_164182_a8c7a3c6d8c39ad04107b64162a78bd5.pdf