Baqiyatallah University of Medical Sciences Hospital Practices and Research 2476-390X 7 1 2022 02 01 The Anti-inflammatory Role of Curcumin in Osteoarthritis: An Overview of Molecular and Radiologic Changes 1 3 150583 10.34172/hpr.2022.01 EN Reza Gerami Department of Radiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran 0000-0001-5034-4141 Ramezan Jafari Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0003-1099-4259 Niloufar Nazeri Mashhad University of Medical Sciences, Mashhad, Iran Amin Saburi Chemical Injuries Research Center, Systemic Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0001-7743-8244 Journal Article 2021 04 24 Osteoarthritis (OA) is the most common form of arthritis, causing pain and progressive disability in millions of people worldwide. The commonly prescribed medications for OA, including non-steroidal anti-inflammatory drugs, have many side effects which has led the scientists to consider safer drugs as an alternative. Therapeutic effects of Curcumin on OA are increasingly declared, and its various aspects in suppressing inflammation and reducing the disease progression are examined more thoroughly. This study aims to discuss curcumin and OA to help scientists working in these fields. In this brief review, we took a look at OA pathogenesis, the role of the immune system, and the biomarkers involved in the onset and progression of the disease. We focused on available data on the anti-inflammatory effect and mechanism of treatment by curcumin on OA. https://www.jhpr.ir/article_150583_877289d6f8b1c36bc3167e772f63cad9.pdf