Baqiyatallah University of Medical Sciences Hospital Practices and Research 2476-390X 4 1 2019 02 01 Improvement of Psychological Symptoms After Replacement Therapy With Levothyroxine in Hypothyroidism: A Report of 2 Cases 39 41 82764 10.15171/hpr.2019.06 EN Reza Bidaki Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-5482-9143 Bita Tavana Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran 0000-0001-6375-4916 Shima Hosseini Kharazmi University, Tehran, Iran Negar Neshati School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-5622-3313 Mojtaba Babaei Zarch School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 0000-0002-6976-7213 Journal Article 2018 08 20  <br /> <strong>Introduction: </strong>Hypothyroidism is a common disorder of the endocrine system in which the production of thyroid hormones is inadequate. In addition to various physical manifestations, patients who suffer from hypothyroidism may also present with psychological problems, as described in previous studies.<br /> <strong>Case Presentation: </strong>Herein, the reports of 2 patients who suffered from hypothyroidism and experienced improvement in their psychological symptoms after levothyroxine therapy are presented. The patients referred with depressive mood with psychotic features and psychomotor retardation. Treatment simultaneously with psychopharmacotherapy and hormone therapy was considered.<br /> <strong>Conclusion: </strong>Although hypothyroidism and depressive disorders are separate issues, hypothyroidism can induce depression and psychosis, and psychopharmacotherapy plus hormone therapy can be effective and boost treatment. https://www.jhpr.ir/article_82764_4556ed716bc312dff084dd743caeca87.pdf