Baqiyatallah University of Medical Sciences Hospital Practices and Research 2476-390X 4 3 2019 09 01 Viral Etiological Factors Causing Acute Encephalitis Syndrome (AES) In Gaya Division, India 92 96 93164 10.15171/hpr.2019.18 EN Roshan Kamal Topno Department of Epidemiology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India 0000-0003-1412-7566 Krishna Pandey Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India 0000-0001-5930-2458 Banke Bihari Singh Department of Pediatrics, Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya- 823001, India Manas Ranjan Dikhit Department of Bioinformatics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India 0000-0002-9131-8975 Ashish Kumar Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India Maneesh Kumar Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India 0000-0002-0231-7162 Ganesh Chandra Sahoo Department of Bioinformatics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India 0000-0002-3560-9815 Vidya Nand Rabidas Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India Niyamat Ali Siddiqui Department of Bio-Statistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India Wakil Paswan Department of Pediatrics, Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya- 823001, India Arjun Lal Department of Microbiology, Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya-823001, India Diwakar Singh Dinesh Department of Vector Biology and Control, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India 0000-0001-8329-6772 Pradeep Das Department of Molecular Biology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, India 0000-0002-7796-6546 Journal Article 2019 05 11 <strong>Background: </strong>From Gaya and adjoining regions, the trend in patients admitted with acute neurological illness was investigated. Illnesses were identified as sudden outbreaks of Japanese virus encephalitis (JE), Herpes simplex virus encephalitis (HSV-1&2), and other acute encephalitis syndrome (AES).<br /> <strong>Objective: </strong>In the current study, an investigation was carried out to assess potential infectious pathogens in patients aged 16 years or younger who were admitted to Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya, with encephalitis-like symptoms.<br /> <strong>Methods: </strong>Cross-epidemiological, serological, and molecular biological studies were performed on samples collected from 71 patients below 16 years of age. Patients’ clinical histories, i.e. fever, socio-demographic characteristics, and other clinical data, were extracted from patient files.<br /> <strong>Results: </strong>The results showed confirmed AES cases, including 49.30% JE and 7.04% HSV positive patients. A higher case-fatality rate of 40% in JE and 40% HSV cases below 7 years of age were observed during treatment would become an unavoidable concern. The epidemical sex ratio was observed to be higher in girls than in boys (1.26:1).<br /> <strong>Conclusion: </strong>The results suggested that JE virus was found to be a main causative risk factor responsible for disease transmission in the outbreak area. https://www.jhpr.ir/article_93164_f51909883261e6203411665223211cba.pdf