Hyponatremia in Moderate and Severe Traumatic Brain Injury

Document Type : Original Article

Authors

1 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Isfahan, Iran

3 Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract
Background: Sodium disorders are one of the most important electrolyte disorders among brain trauma patients.
Objectives: The purpose of this study was to determine the frequency of hyponatremia in patients with moderate and severe brain trauma and its relationship with disease prognosis.
Methods: This descriptive-cross-sectional and prospective study was conducted on brain trauma patients visiting Kashani Hospital in Isfahan city in 2023. The obtained data was analyzed by SPSS 24.
Results: Out of the 54 examined (23 severe TBI and 31 moderate TBI) patients, hypernatremia was observed in seven cases (13%), and hyponatremia was observed in 23 cases (42.7%). Hyponatremia on the first day had a significant relationship with the bad prognosis of the disease. In addition, a significant relationship was observed between the type of imaging findings and GOS, so that people who had ICH imaging findings were associated with a poorer prognosis p <0.05.
Conclusion: On the first day, hyponatremia had a significant prevalence in moderate and severe brain trauma patients, which was associated with a bad prognosis of the disease, and this relationship is not dependent on factors such as age, gender, and cause of trauma.

Keywords


  1. Davoodabadi A, Yazdani A, Sayyah M, Mirzadeh Javaheri M. Trauma epidemiology and its consequences in victims referred to Kashan Trauma Center during 2007-8. Feyz. 2011;14(5):500-5.
  2. Galgano M, Toshkezi G, Qiu X, Russell T, Chin L, Zhao LR. Traumatic brain injury: current treatment strategies and future endeavors. Cell Transplant. 2017; 26(7):1118-30. doi:10.1177/0963689717714102
  3. Ahmed S, Venigalla H, Mekala HM, Dar S, Hassan M, Ayub S. Traumatic brain injury and neuropsychiatric complications. Indian J Psychol Med. 2017;39(2):114-21. doi:10.4103/0253-7176.203129
  4. Dash HH, Chavali S. Management of traumatic brain injury patients. Korean J Anesthesiol. 2018;71(1):12-21. doi:4097/kjae.2018.71.1.12
  5. Moradi Moghaddam O, Niyakan Lahiji M, Hassani V, Kazemi Gezik F, Farazi E. Relationship between type of brain injury with Bispectral Index monitoring in intubated ICU trauma patients. Tehran Univ Med J. 2015;73(2):117-26.
  6. Yousefi Abdolmaleki E, Teymourzadeh Baboli M, Abedi Samakoosh M, Shirzad M, Babamahmoodi F. Hyponatremia and Dependent Factors in Admitted Patients with Tuberculosis at Razi Teaching Hospital, North of Iran 2006-2011. J Mazandaran Univ Med Sci. 2013;22(97):12-6.
  7. Sahay M, Sahay R. Hyponatremia: A practical approach. Indian J Endocrinol Metab. 2014;18(6):760-71. doi:10.4103/2230-8210.141320
  8. Mohan S, Gu S, Parikh A, Radhakrishnan J. Prevalence of hyponatremia and association with mortality: results from NHANES. Am J Med. 2013; 126(12):1127-37. doi:10.1016/j.amjmed.2013.07.021
  9. Mentrasti G, Scortichini L, Torniai M, Giampieri R, Morgese F, Rinaldi S, et al. Syndrome of inappropriate antidiuretic hormone secretion (SIADH): optimal management. Ther Clin Risk Manag. 2020:663-72.
  10. Nourian SM, Nematbakhsh M, Sabori M, Rezvanian H, Pioorozbakht A, Hashemi PS. Hyponatremia and the syndrome of inappropriate secretion of antiduretic hormone (siadh) after spinal surgery. 2000; 7(1):61-6.
  11. Yasir M, Mechanic OJ. Syndrome of inappropriate antidiuretic hormone secretion. StatPearls Publishing; 2019.
  12. Sabouri M, Moradian Lotfi H, Norian SM. Assay of serum Sodium balance disturbance in spontaneous subarachnoid hemorrhage and relation to prognosis of disease. Avicenna J Clin Med. 2006;13(2):5-9.
  13. Mokhtari M, Koochak M, Goharani R, Miri M, Araghi PE. Frequency of hyper-and hypo-natremia in patients admitted in the ICU & comparison of their association with mortality. Res Med. 2010;33(3):183-8.