Medication Adherence to the Pharmacological Treatment and Health Literacy in Patients with Rheumatoid Arthritis

Document Type : Original Article

Author

Department of Physical Medicine and Rehabilitation, School of Medicine, Düzce University, Düzce, Turkey

Abstract
Background: Treatment adherence is a critical factor in controlling symptoms and determining the success of treatment in chronic disease management.
Objectives: The aim of this study was to investigate the relationship between health literacy levels and adherence to pharmacological treatment in patients with Rheumatoid Arthritis (RA).
Methods: This cross-sectional study included 196 patients. The mean age of participants was 47.35 ± 15.95 years. Socio-demographic and clinical characteristics of the patients were recorded. Health literacy levels were assessed using the Türkiye Health Literacy-32 (THL-32) Scale. Medication adherence to the pharmacological treatment was assessed using the Medication Adherence Report Scale (MARS).
Results: THL-32 and MARS scores were compared according to the demographic characteristics, and a significant difference was found between the education level and place of residence groups. A multivariate regression model was used to assess the connection between them. Health literacy was found to be 3.88 times higher in urban areas compared to rural areas, 4.12 times higher in those with high school education compared to primary school, and 4.39 times higher in those with higher education compared to other levels. In terms of medication adherence, it was found to be 4.18 times higher in urban areas compared to rural areas, 3.1 times higher in those with high school education compared to primary school, and 3.6 times higher in those with higher education compared to other levels.
Conclusion: This study demonstrated that health literacy is positively associated with medication adherence in patients with rheumatoid arthritis. These findings highlight the importance of focusing on health literacy to improve adherence to treatment. Health professionals should prioritize enhancing health literacy to support better disease self-management and treatment outcomes.

Keywords


  1. World Health Organisation. Global Status Report on Noncommunicable Diseases. 2010; Available from: http://www.who.int/nmh/publications/ncd_report2010/en/
  2. Ratzan SC. Health literacy: communication for the public good. Health Promot Int. 2001;16(2):207-14. doi:10.1093/heapro/16.2.207
  3. Kickbusch I, Pelikan JM, Apfel F, Tsouros AD. Health literacy the solid facts. Copenhagen: WHO Regional Office for Europe; 2013. Available from: https://apps. who.int/iris/bitstream/handle/10665/128703/e96854.pdf
  4. Çopurlar CK, Kartal M. What is Health Literacy? How to Measure It? Why is It Important? TJFMPC. 2016; 10:42-7.
  5. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham III CO, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9): 2569-81. doi:10.1002/art.27584
  6. Okyay P, Abacıgil F. Trkiye Sağlık Okuryazarlığı lekleri Gvenilirlik ve Geerlilik alışması. Republic of Turkey Ministry of Health. 2016. pp.99.
  7. Stirratt MJ, Dunbar-Jacob J, Crane HM, Simoni JM, Czajkowski S, Hilliard ME, et al. Self-report measures of medication adherence behavior: recommendations on optimal use. Transl Behav Med. 2015;5(4):470-82. doi:10.1007/s13142-015-0315-2
  8. Esin TŞ, Hanife SB, Dilşad S. The validity and reliability study of the Turkish adaptation of medical adherence report scale. J Ist Faculty Med. 2019;82(1): 52-61. doi:26650/IUITFD.413637
  9. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-60. doi:10.3758/BRM.41. 4.1149
  10. Faul F, Erdfelder E, Lang AG, Buchner A. G* Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175-91. doi:10.3758/BF03 193146
  11. Caplan L, Wolfe F, Michaud K, Quinzanos I, Hirsh JM. Strong association of health literacy with functional status among rheumatoid arthritis patients: a cross‐sectional study. Arthritis Care Res. 2014;66 (4):508-14. doi:10.1002/acr.22165
  12. Sultan AA, Ozturk FO. Health literacy levels of women and related factors in Turkey. J Nurs Res. 2021; 29(6):e180. doi:10.1097/JNR.0000000000000452
  13. Hirsh JM, Boyle DJ, Collier DH, Oxenfeld AJ, Nash A, Quinzanos I, Caplan L. Limited health literacy is a common finding in a public health hospital's rheumatology clinic and is predictive of disease severity. J Clin Rheumatol. 2011;17(5):236-41. doi:10.1097/RHU.0b013e318226a01f
  14. Buchbinder R, Hall S, Youd JM. Functional health literacy of patients with rheumatoid arthritis attending a community-based rheumatology practice. J Rheumatol. 2006;33(5):879-86.
  15. Srensen K, Pelikan JM, Rthlin F, Ganahl K, Slonska Z, Doyle G, et al. Health literacy in Europe: comparative results of the European health literacy survey (HLS-EU). Eur J Public Health. 2015;25(6): 1053-8. doi:10.1093/eurpub/ckv043
  16. Kickbusch I, Pelikan JM, Apfel F, Tsouros AD. Health literacy. The solid facts. Copenhagen: WHO Regional Office for Europe; 2013.
  17. Gazmararian J, Jacobson KL, Pan Y, Schmotzer B, Kripalani S. Effect of a pharmacy-based health literacy intervention and patient characteristics on medication refill adherence in an urban health system. Ann Pharmacother. 2010;44(1):80-7. doi:10.1345/aph.1M 328
  18. Murphy DA, Lam P, Naar-King S, Harris DR, Parsons JT, Muenz LR, Adolescent Medicine Trials Network for HIV/AIDS Interventions. Health literacy and antiretroviral adherence among HIV-infected adolescents. Patient education and counseling. 2010; 79(1):25-9. doi:10.1016/j.pec.2009.07.014
  19. Institute of Medicine (U.S.). Forum on the Science of Health Care Quality Improvement and Implementation, Chao S, Anderson K, et al. Toward health equity and patient-centeredness: Integrating health literacy, disparities reduction, and quality improvement: Workshop summary. Washington, D.C.: National Academies Press; 2009:85.
  20. Anghel LA, Farcaş AM, Oprean RN. Medication adherence and persistence in patients with autoimmune rheumatic diseases: a narrative review. Patient Prefer Adherence. 2018:1151-66.