Cutaneous Larva Migrans: Clinical Challenges and Insights from a Case Report with a Literature Review

Document Type : Case Report

Authors

1 Department of Parasitology and Mycology, School of Medicine, Arak University of Medical Sciences, Arak, Iran

2 Department of Biology, Payame Noor University (PNU), Tehran, Iran

3 Doctor of Medicine, General Practitioner, Arak, Iran

4 Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Abstract
Background: Cutaneous larva migrans (CLM) is a parasitic infection caused by the accidental penetration of canine hookworm larvae into the superficial layers of human skin. Although typically self-limiting, delayed diagnosis may result in complications such as secondary infections or allergic reactions.
Case Presentation: The case involved a 54-year-old man with a history of hypertension who presented with a creeping, erythematous lesion on his left leg, accompanied by severe pruritus and a history of contact with a pet dog. After confirming the dog’s hookworm infection and conducting further clinical evaluation, a diagnosis of CLM was established. Treatment with albendazole and an antihistamine resulted in complete resolution of the patient’s symptoms.
Conclusion: Although CLM is typically a self-limiting condition, timely initiation of treatment can significantly reduce the duration and severity of symptoms. The growing trend of pet ownership has increased the risk of CLM transmission, underscoring the importance of implementing effective preventive measures.

Keywords


  1. Rodriguez-Morales AJ, Gonz lez-Leal N, Montes-Montoya MC, Fern ndez-Esp ndola L, Bonilla-Aldana DK, Aze as-Burgoa JM, et al. Cutaneous larva migrans. Curr Trop Med Rep. 2021;8:190-203. doi:10.1007/s40475-021-00239-0
  2. Hochedez P, Caumes E. Hookworm‐related cutaneous larva migrans. J Travel Med. 2007;14(5):326-33. doi:10.1111/j.1708-8305.2007.00148.x
  3. Hawdon JM, Wise KA. Ancylostoma caninum and other canine hookworms. Dog parasites endangering human health. Parasitology Research Monographs, Springer, Cham. 2021. pp. 147-93. doi:10.1007/978-3-030-53230-7_9
  4. Stufano A, Foti C, Lovreglio P, Romita P, De Marco A, Lia RP, Otranto D, Iatta R. Occupational risk of cutaneous larva migrans: A case report and a systematic literature review. PLoS Negl Trop Dis. 2022;16(5):e0010330. doi:10.1371/journal.pntd.00 10330
  5. Shrestha A, Kusha KC, Baral A, Shrestha R, Shrestha R. Cutaneous larva migrans in a child: a case report and review of literature. Ann Med Surg. 2024;86(1):530-4. doi:10.1097/MS9.0000000000001512
  6. Osman S, Tarnari N, Ahsan A, Ahmed KA. Cutaneous Larva Migrans (CLM) may not be easy to diagnose: a case report and narrative review. Oxf Med Case Rep. 2024;2024(4):omae025. doi:10.1093/omcr/omae025
  7. Kuna A, Olszański R, Sikorska K. Cutaneous Larva Migrans as a frequent problem in travellers. Int Marit Health. 2023;74(4):259-64. doi:10.5603/IMH.2023. 0045
  8. Bowman DD, Montgomery SP, Zajac AM, Eberhard ML, Kazacos KR. Hookworms of dogs and cats as agents of cutaneous larva migrans. Trends Parasitol. 2010;26(4):162-7. doi:10.1016/j.pt.2010.01.005
  9. Feldmeier H, Schuster A. Mini review: Hookworm-related cutaneous larva migrans. Eur J Clin Microbiol Infect Dis. 2012;31:915-8. doi:10.1007/s10096-011-1404-x
  10. Leung AK, Barankin B, Hon KL. Cutaneous larva migrans. Recent Pat Inflamm Allergy Drug Discov. 2017;11(1):2-11. doi:10.2174/1872213X116661701 10162344
  11. Wesołowski R, Mila-Kierzenkowska C, Pawłowska M, Szewczyk-Golec K, Kałużna L, Woźniak AM. Cutaneous larva migrans imported from a tropical trip-case report and literature review. Ann Agric Environ Med. 2021;28(4):709-12. doi:10.26444/aaem/131600
  12. Ryguła A, Kowalsk M, Hryncewicz-Gwóźdź A, Maj J, Jankowska-Konsur A. Cutaneous larva migrans–case report and literature review. Fam Med Prim Care Rev. 2023;25(3):367-70. doi:10.5114/fmpcr.2023.130099
  13. Sil A, Bhanja DB, Chandra A, Biswas SK. Loeffler’s Syndrome and Multifocal Cutaneous Larva Migrans: Case report of an uncommon occurrence and review of the literature. Sultan Qaboos Univ Med J. 2023;23(1):104-8. doi:18295/squmj.5.2022.036
  14. Can İ, Yürekli A. Effect of global warming on dermatology practice: the increase in cases of cutaneous larva migrans in the eastern Black Sea region of Turkey. J Cosmet Dermatol. 2022;21(9): 3929-33. doi:10.1111/jocd.15128
  15. Basit A, Yasin U, Hashmi HA, Kiran A, Ali H, Keerio BY, et al. Pets Diseases and Public Health: Zoonosis, Transmission and Treatment: A Review. Indus J Biosci Res. 2024;2(02):1059-71. doi:10.70749/ijbr.v2i02. 327