Hospital Practices and Research

Synergizing Regeneration and Pharmacology: Metformin-Loaded MSC Exosomes as a Biologically Intelligent Strategy for Myocardial Repair

Articles in Press

Editorial

Authors

Mostafa Akbariqomi 1
Reza Heidari 2

1 Tissue Engineering and Regenerative Medicine Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Cancer Epidemiology Research Center (AJA-CERTC), AJA University of Medical Sciences, Tehran, Iran

10.30491/hpr.2026.244723
Abstract
Despite remarkable advances in reperfusion strategies, antithrombotic therapy, and secondary prevention, myocardial infarction (MI) remains a leading cause of heart failure and cardiovascular mortality worldwide. Among emerging regenerative approaches, exosome engineering has attracted considerable scientific interest. Exosomes are nano-sized extracellular vesicles secreted by nearly all cell types and are now recognized as highly organized mediators of intercellular communication. By transporting microRNAs, proteins, lipids, and signaling molecules, exosomes influence gene expression and cellular behavior in target tissues. We argue that integrating metabolic modulators with engineered exosome delivery platforms represents not merely an incremental innovation but a paradigm shift in post-MI regenerative therapy.

Keywords

Exosome
Metformin
Regeneration
Myocardial Infarction
Mesenchymal Stem Cell
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Hospital Practices and Research

Articles in Press, Accepted Manuscript
Available Online from 30 March 2026

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