Hospital Practices and Research

A Promising Path for Gastritis Treatment: Policy Recommendation for the Integration of Scrophularia striata Based on Anti-Ulcer Scientific Evidence

Articles in Press

Authors

Mohammad Hossein Mikaeili 1
Zahra Bahari 2

1 Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

10.30491/hpr.2026.256771
Abstract
This study investigated the therapeutic potential of the hydro-alcoholic extract of Scrophularia striata (S. striata) for treating ethanol-induced gastritis in Wistar rats. Gastritis was experimentally induced to assess the protective and healing effects of the extract. A total of 24 rats were treated with the extract at a dose of 100 mg/kg for 14 days. The ulcer index and gene expression levels of Annexin A1 (AnxA1), Phospholipase A2 (PLA2), and inducible nitric oxide synthase (iNOS) were analyzed to evaluate the anti-inflammatory and tissue-repairing properties of the extract. Results showed a 52.77% reduction in ulcer severity, with significant upregulation of AnxA1 and downregulation of PLA2 and iNOS. These findings indicate that S. striata modulates key inflammatory pathways to promote gastric mucosal healing. The study supports the traditional use of S. striata in treating gastrointestinal disorders and highlights its potential as a natural therapeutic agent. It also emphasizes the importance of integrating traditional medicine with modern biomedical research to develop effective, plant-based treatments for common health issues like gastritis.

Keywords

Gastritis
Scrophularia striata
Annexin-A1
Phospholipase-A2
iNOS
1.    Rasheed SAA, Afroz AT, Sajjad AST, Ahmad SRR. Gastritis: Etiology, Pathophysiology, Diagnosis, and Management. Int J Eng Sci Technol. 2025;13:1
2.    Malfertheiner P, Mégraud F, O'Morain CA, Gisbert JP, Kuipers EJ, Axon AT, et al. Management of Helicobacter pylori infection—the Maastricht V/Florence consensus report. Gut. 2017;66(1):6-30. doi:10.1136/gutjnl-2016-312288
3.    Kalladka SS, Mohan R, Shetty P, Patil P. Significance of phospholipase A2 inhibitor Annexin A1 in type 2 diabetes mellitus with foot ulcers. J Appl Pharm Sci. 2024;14(1):170-6. doi:10.7324/JAPS.2024.147471
4.    Shahsavari S. A brief review of the medicinal effects of Scrophularia striata. J Biochem Phytomed. 2024;3(1): 18-20. doi:10.34172/jbp.2024.6 
Hospital Practices and Research

Articles in Press, Accepted Manuscript
Available Online from 10 November 2026

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