Document Type : Case Report


1 Medicine, Quran and Hadith Research Center Baqiyatallah University of Medical Sciences, Tehran, IR Iran

2 Medicine, Quran and Hadith Research Center & Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran


Introduction: Homeopathy can be applied to treat various diseases and conditions such as cancer, allergy, mood disorders, headache and pain. This case showed that homeopathic medicine can be a treatment modality for idiopathic thrombocytopenic purpura (ITP), an autoimmune-mediated hematologic disorder.
Case Presentation: The patient was a 5.5–year-old child with ITP who referred to the homeopathic clinic with extensive petechiae and purpura on her body. Her platelet count was 15000/mcL and her anti-dsDNA and ANA were negative on her first visit. Her disease had first been diagnosed at the age of 2.5 years. She had undergone routine therapy for ITP; however, despite 15 months of corticosteroid therapy and IVIG injections, her platelet count was still low. After treatment with homeopathic remedies, her platelet count increased and signs of ITP disappeared.
Conclusion: Homeopathic remedies can be considered as complementary and alternative medicines for ITP treatment protocols.


  1. Teut M, Lüdtke R, Schnabel K, Willich SN, Witt CM. Homeopathic treatment of elderly patients-a prospective observational study with follow-up over a two year period. BMC Geriatr. 2010;10(1):10. [DOI]
  2. Rostock M, Naumann J, Guethlin C, Guenther L, Bartsch HH, Walach H. Classical homeopathy in the treatment of cancer patients-a prospective observational study of two independent cohorts. BMC Cancer. 2011;11(1):19. [DOI]
  3. Längler A, Spix C, Edelhäuser F, Kameda G, Kaatsch P, Seifert G. Use of homeopathy in pediatric oncology in Germany. Evid Based Complement Alternat Med. 2010;2011.
  4. de Carvalho AC, Bonamin LV. Viscum album (L) extracts in cancer treatment: a systematic review of in vitro and in vivo studies. Int J High Dilut Res. 2015;14(2).
  5. Tenti E, Gardini AC, Nanni O, Foca F, Cumero S. Use of non-conventional medicines by cancer patients. Eur J Oncol. 2015;19(3):144-9.
  6. Bishayee K, Mondal J, Sikdar S, Khuda-Bukhsh AR. Condurango (Gonolobus condurango) Extract Activates Fas Receptor and Depolarizes Mitochondrial Membrane Potential to Induce ROS-dependent Apoptosis in Cancer Cells in vitro: CE-treatment on HeLa: a ROS-dependent mechanism. J Pharmacopuncture. 2015;18(3):32-41. [DOI]
  7. Sikdar S, Kumar Saha S, Rahman Khuda-Bukhsh A. Relative Apoptosis-inducing Potential of Homeopa-thic Condurango 6C and 30C in H460 Lung Cancer Cells In vitro: -Apoptosis-induction by homeopathic Condurango in H460 cells. J Pharmacopuncture. 2014;17(1):59-69. [DOI]
  8. Banerjee K, Costelloe C, Mathie RT, Howick J. Homeopathy for allergic rhinitis: protocol for a systematic review. Syst Rev. 2014;3(1):59. [DOI]
  9. Solelhac G, Charpin D. Management of allergic rhinitis. F1000Prime Rep. 2014;6:94. [DOI]
  10. Roll S, Reinhold T, Pach D, Brinkhaus B, Icke K, Staab D, et al. Comparative effectiveness of homoeopathic vs. conventional therapy in usual care of atopic eczema in children: long-term medical and economic outcomes. PLoS One. 2013;8(1):e54973. [DOI]
  11. Naidoo P, Pellow J. A randomized placebo-controlled pilot study of Cat saliva 9cH and Histaminum 9cH in cat allergic adults. Homeopathy. 2013;102(2):123-9. [DOI]
  12. Eizayaga JE, Eizayaga JI. Prospective observational study of 42 patients with atopic dermatitis treated with homeopathic medicines. Homeopathy. 2012;101(1):21-7. [DOI]
  13. Shafei HF, AbdelDayem SM, Mohamed NH. Individualized homeopathy in a group of Egyptian asthmatic children. Homeopathy. 2012;101(4):224-30. [DOI]
  14. Chandrakant Nimgulkar C, Dattatray Patil S, Dinesh Kumar B. Anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture. Homeopathy. 2011;100(3):138-43. [DOI]
  15. Grundling C, Schimetta W, Frass M. Real-life effect of classical homeopathy in the treatment of allergies: A multicenter prospective observational study. Wien Klin Wochenschr. 2012;124(1-2):11-7. [DOI]
  16. Rossi E, Bartoli P, Bianchi A, Da Fre M. Homeopathy in paediatric atopic diseases: long-term results in children with atopic dermatitis. Homeopathy. 2012;101(1):13-20. [DOI]
  17. Qureshi NA, Al-Bedah AM. Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatr Dis Treat. 2013;9:639-58. [DOI]
  18. Adler UC, Krüger S, Teut M, Lüdtke R, Schützler L, Martins F, et al. Homeopathy for depression: A randomized, partially double-blind, placebo-controlled, four-armed study (DEP-HOM). PLoS One. 2013;8(9):e75537. [DOI]
  19. del Carmen Macías-Cortés E, Llanes-González L, Aguilar-Faisal L, Asbun-Bojalil J. Individualized Homeopathic Treatment and Fluoxetine for Moderate to Severe Depression in Peri-and Postmenopausal Women (HOMDEP-MENOP Study): A Randomized, Double-Dummy, Double-Blind, Placebo-Controlled Trial. PLoS One. 2015;10(3):e0118440. [DOI]
  20. Schröder D, Weiser M, Klein P. Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study. Eur J Heart Fail. 2003;5(3):319-26. [DOI]
  21. Mehra P. Usefulness of homoeopathy in essential hypertension: an exploratory interventional trial. Int J High Dilut Res. 2015;14(1):16-9.
  22. Koley M, Saha S, Ghosh S. A double-blind randomized placebo-controlled feasibility study evaluating individualized homeopathy in managing pain of knee osteoarthritis. J Evid Based Complementary Altern Med. 2015;20(3):186-91. [DOI]
  23. Kundu T, Shaikh A, Kutty A, Nalvade A, Kulkarni S, Kulkarni R, et al. Homeopathic medicines substantially reduce the need for clotting factor concentrates in haemophilia patients: results of a blinded placebo controlled cross over trial. Homeopathy. 2012;101(1):38-43. [DOI]
  24. Posadzki P, AlBedah A, Khalil MM, AlQaed MS, Lee MS, Ernst E, et al. Complementary and alternative medicine for the prevention and treatment of migraine headache: an overview of systematic reviews. Focus Altern Complement Ther. 2015;20(2):58-73. [DOI]
  25. Danno K, Colas A, Masson JL, Bordet MF. Homeopathic treatment of migraine in children: results of a prospective, multicenter, observational study. J Altern Complement Med. 2013;19(2):119-23. [DOI]
  26. Simpson CA. Complementary Medicine in Chronic Pain Treatment. Phys Med Rehabil Clin N Am. 2015;26(2):321-47. [DOI]
  27. Kelley BP, Shauver MJ, Chung KC. Management of Acute Postoperative Pain in Hand Surgery: A Systematic Review. J Hand Surg. 2015;40(8):1610-9. e1.
  28. Alam MM. Idiopathic thrombocytopenic purpura in children: a 10 years experience at tertiary care hospital. J Pak Med Assoc. 2014;64(12):1358-62.
  29. Kikuchi K, Miyakawa Y, Ikeda S, Sato Y, Takebayashi T. Cost-effectiveness of adding rituximab to splenectomy and romiplostim for treating steroid-resistant idiopathic thrombocytopenic purpura in adults. BMC Health Serv Res. 2015;15(1):2. [DOI]
  30. Dash CH, Gillanders KR, Stratford Bobbitt ME, Gascoigne EW, Leach SJ. Safety and efficacy of Gammaplex(R) in idiopathic thrombocytopenic purpura ( PLoS One. 2014;9(6):e96600. [DOI]
  31. Ramakrishna R, Rehman A, Ramakrishna S, Alexander W, Yeo W. Use of Romiplostim in Patients with Chronic Idiopathic Thrombocytopenic Purpura (cITP) During Peri‐Operative Period. Internal Med J. 2015.
  32. Zhou H, Xu M, Qin P, Zhang H-y, Yuan C-l, Zhao H-g, et al. A multicenter randomized open-label study of rituximab plus rhTPO vs rituximab in corticosteroid-resistant or relapsed ITP. Blood. 2015;125(10):1541-7. [DOI]
  33. Vecchio R, Intagliata E, La Corte F, Marchese S, Cacciola RR, Cacciola E. Late Results After Splenectomy in Adult Idiopathic Thrombocytopenic Purpura. JSLS. 2015;19(1).
  34. Walsh AV, Collados NJ, Andújar MC, Gomez CG, Candel GR, Paniagua SP, et al. DI-077 Use of romiplostim in patients with idiopathic thrombocytopenic purpura. Eur J Hospl Pharm. 2015;22(Suppl 1):A108-A9.
  35. Clark WF, Rock G, Barth D, Arnold DM, Webert KE, Yenson PR, et al. A phase-II sequential case-series study of all patients presenting to four plasma exchange centres with presumed relapsed/refractory thrombotic thrombocytopenic purpura treated with rituximab. Br J Haematol. 2015;170(2):208-17. [DOI]