Improvement of Psychological Symptoms After Replacement Therapy With Levothyroxine in Hypothyroidism: A Report of 2 Cases

Bidaki, Reza; Tavana, Bita; Hosseini, Shima; Neshati, Negar; Babaei Zarch, Mojtaba

doi:10.15171/hpr.2019.06

Improvement of Psychological Symptoms After Replacement Therapy With Levothyroxine in Hypothyroidism: A Report of 2 Cases

Document Type : Case Report

Authors

Reza Bidaki ¹^{, 2}

Bita Tavana ³

Shima Hosseini ⁴

Negar Neshati ⁵

Mojtaba Babaei Zarch ⁵

¹ Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

² Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

³ Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

⁴ Kharazmi University, Tehran, Iran

⁵ School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

10.15171/hpr.2019.06

Abstract

Introduction: Hypothyroidism is a common disorder of the endocrine system in which the production of thyroid hormones is inadequate. In addition to various physical manifestations, patients who suffer from hypothyroidism may also present with psychological problems, as described in previous studies.
Case Presentation: Herein, the reports of 2 patients who suffered from hypothyroidism and experienced improvement in their psychological symptoms after levothyroxine therapy are presented. The patients referred with depressive mood with psychotic features and psychomotor retardation. Treatment simultaneously with psychopharmacotherapy and hormone therapy was considered.
Conclusion: Although hypothyroidism and depressive disorders are separate issues, hypothyroidism can induce depression and psychosis, and psychopharmacotherapy plus hormone therapy can be effective and boost treatment.

Keywords

Hypothyroidism

Persecutory Delusion

Psychological Disturbance

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